Breakdown: Offline trophies: 12 (7 4 1 )
Online trophies: 0
Time to 100%: ~5 Hours. Less if you follow the walkthrough.
Playthroughs needed: 1 (with some creative saving)
Missable Trophies: Everything except "Challenge of the Sphunx," "Looters of the Lost Toybox," "Mystery on the Disorient Express," and "Horror Show" are missable.
Glitched Trophies: There are no specific trophies that are glitched as of yet, but a few glitches with game itself have been found which you can read about in this thread.
Play through the game using the walkthrough I've written here. If you reference this and the trophy guide you'll have everything except Secret Handshake after you finish the game. Make a separate save when instructed.
Reload the save from above to get Secret Handshake, which should be your final trophy.
[PS3T Would Like to Thank Lonesheep for this Road Map]