Mysteries of the Tartarus Trophy in End Space

Story related cannot be missed.

This trophy is earned by completing the eleventh mission after the tutorial. This is easily the most difficult mission in the game. You are tasked with destroying a heavily fortified research station. Once you reach a certain point in the level you will be fighting against an unknown enemy along with the resistance. The unknown enemy has better ships and weapons than you or the resistance do. I suggest trying to keep your distance as best you can and unloading with missiles and the plasma gun. I also took out the capital class resistance ships as soon as possible but that isn’t required. You will likely die a few times before finding a run that works for you.