Finish the game using Hysteria only once
You can do this on either your first or second playthrough. We advise doing this on your second playthrough. That way you will have all your weapons upgraded and they will do more damage. Make sure you never press the button to activate Hysteria. You don't need to use Hysteria at all to earn this trophy, the trophy will still pop at the end when the credits start to roll, along as you didn't use it more than once. The only way to use it is to be on one heart or less, you will then be prompted to press . It will let you do more damage and your weapons will have unlimited ammo.
Please see Madness Prevails for more info on how to go about completing the game.
After completing the game, you will have a option to start a new game with New Game+, Start the game that way and let that chapter finish, quit out and then go to chapter select and choose the last sub chapter of the last level, walk to the end to have the credits start. You can either watch the credits or skip them, the trophy will soon follow.